Biguanide
An Established Pharmacologic Class (EPC) in the FDA NDC Directory: the class FDA records for a product in its PHARM_CLASSES field.
In the NADAC file of 2026-10-14
73 products in the NADAC file of 2026-10-14 have an NDC that FDA lists in this class, covering 24 nonproprietary names as FDA writes them. 65 of them have a Medicare figure on OpenBill.
Being in one class means FDA describes the drugs’ pharmacology the same way. It does not mean one can replace another; that is a question for your prescriber.
Prices per unit: CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · as of 2026-10-14 · retrieved 2026-10-17. Classes: FDA NDC Directory · ndctext.zip · as of 2026-10-16.
The products, with what pharmacies pay per unit
- ALOGLIPTIN-METFORMIN 12.5-1000 $2.46491 per EA · eff. 2026-09-23 filed Medicare figure
- ALOGLIPTIN-METFORMIN 12.5-500 $2.3206 per EA · eff. 2026-09-23 filed Medicare figure
- DAPAGLIFLOZIN-METFORMIN ER 10-1,000 MG TABLET $0.71952 per EA · eff. 2026-09-23 filed Medicare figure
- DAPAGLIFLOZIN-METFORMIN ER 10-500 MG TABLET $0.80198 per EA · eff. 2026-09-23 filed Medicare figure
- DAPAGLIFLOZIN-METFORMIN ER 5-1,000 MG TABLET $0.46063 per EA · eff. 2026-09-23 filed Medicare figure
- DAPAGLIFLOZIN-METFORMIN ER 5-500 MG TABLET $0.70725 per EA · eff. 2026-09-23 filed Medicare figure
- GLIPIZIDE-METFORMIN 2.5-250 MG $0.2418 per EA · eff. 2026-09-23 filed Medicare figure
- GLIPIZIDE-METFORMIN 2.5-500 MG $0.22051 per EA · eff. 2026-09-23 filed Medicare figure
- GLIPIZIDE-METFORMIN 5-500 MG $0.20234 per EA · eff. 2026-09-23 filed Medicare figure
- GLYBURIDE-METFORMIN 2.5-500 MG $0.17146 per EA · eff. 2026-09-23 filed Medicare figure
- GLYBURIDE-METFORMIN 5-500 MG $0.18963 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET 150-1,000 MG TABLET $9.57542 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET 150-500 MG TABLET $9.60887 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET 50-1,000 MG TABLET $9.53833 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET 50-500 MG TABLET $9.56363 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET XR 150-1,000 MG TAB $9.53579 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET XR 150-500 MG TABLET $9.56119 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET XR 50-1,000 MG TAB $9.68763 per EA · eff. 2026-09-23 filed Medicare figure
- INVOKAMET XR 50-500 MG TABLET $9.67753 per EA · eff. 2025-12-17 filed Medicare figure
- JANUMET 50-1,000 MG TABLET $5.27929 per EA · eff. 2026-09-23 filed Medicare figure
- JANUMET 50-500 MG TABLET $5.28403 per EA · eff. 2026-09-23 filed Medicare figure
- JANUMET XR 100-1,000 MG TABLET $10.55592 per EA · eff. 2026-09-23 filed Medicare figure
- JANUMET XR 50-1,000 MG TABLET $5.27807 per EA · eff. 2026-09-23 filed Medicare figure
- JANUMET XR 50-500 MG TABLET $5.283 per EA · eff. 2026-09-23 filed Medicare figure
- JENTADUETO 2.5 MG-1,000 MG TAB $8.4388 per EA · eff. 2026-09-23 filed Medicare figure
- JENTADUETO 2.5 MG-500 MG TAB $8.44289 per EA · eff. 2026-09-23 filed Medicare figure
- JENTADUETO 2.5 MG-850 MG TAB $8.45431 per EA · eff. 2026-09-23 filed Medicare figure
- JENTADUETO XR 2.5 MG-1,000 MG $8.46945 per EA · eff. 2026-09-23 filed Medicare figure
- JENTADUETO XR 5 MG-1,000 MG TB $16.94698 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN ER 1,000 MG GASTR-TB $0.3357 per EA · eff. 2026-09-23 filed
- METFORMIN ER 1,000 MG OSM-TAB $0.31418 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN ER 500 MG GASTRC-TB $0.27102 per EA · eff. 2026-09-23 filed
- METFORMIN ER 500 MG OSMOTIC TB $0.1644 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN HCL 1,000 MG TABLET $0.02315 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN HCL 500 MG TABLET $0.01451 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN HCL 500 MG/5 ML SOLN $0.3829 per ML · eff. 2026-09-23 filed
- METFORMIN HCL 625 MG TABLET $12.5266 per EA · eff. 2026-01-21 to 2026-02-25 filed Medicare figure
- METFORMIN HCL 750 MG TABLET $14.605 per EA · eff. 2025-12-17 to 2026-02-25 filed Medicare figure
- METFORMIN HCL 850 MG TABLET $0.02398 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN HCL ER 500 MG TABLET $0.02838 per EA · eff. 2026-09-23 filed Medicare figure
- METFORMIN HCL ER 750 MG TABLET $0.05264 per EA · eff. 2026-09-23 filed Medicare figure
- PIOGLITAZONE-METFORMIN 15-500 $0.2835 per EA · eff. 2026-09-23 filed Medicare figure
- PIOGLITAZONE-METFORMIN 15-850 $0.23908 per EA · eff. 2026-09-23 filed Medicare figure
- SAXAGLIPTIN-METFORMIN ER 2.5-1,000 MG TABLET $5.00702 per EA · eff. 2026-09-23 filed Medicare figure
- SAXAGLIPTIN-METFORMIN ER 5-1,000 MG TABLET $9.647 per EA · eff. 2026-09-23 filed Medicare figure
- SEGLUROMET 2.5-1,000 MG TABLET $5.7555 per EA · eff. 2026-09-23 filed Medicare figure
- SEGLUROMET 2.5-500 MG TABLET $5.70117 per EA · eff. 2025-12-17 filed Medicare figure
- SEGLUROMET 7.5-1,000 MG TABLET $5.71171 per EA · eff. 2026-09-23 filed Medicare figure
- SEGLUROMET 7.5-500 MG TABLET $5.73631 per EA · eff. 2026-09-23 filed Medicare figure
- SITAGLIPTIN PHOSPHATE-METFORMIN 50 MG-1,000 MG TABLET $1.75986 per EA · eff. 2026-08-05 filed Medicare figure
- SITAGLIPTIN PHOSPHATE-METFORMIN 50 MG-500 MG TABLET $1.92131 per EA · eff. 2026-08-05 filed Medicare figure
- SYNJARDY 12.5-1,000 MG TABLET $5.60127 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY 12.5-500 MG TABLET $5.61305 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY 5-1,000 MG TABLET $5.59938 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY 5-500 MG TABLET $5.62273 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY XR 10-1,000 MG TABLET $11.21863 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY XR 12.5-1,000 MG TAB $5.59799 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY XR 25-1,000 MG TABLET $11.19287 per EA · eff. 2026-09-23 filed Medicare figure
- SYNJARDY XR 5-1,000 MG TABLET $5.61111 per EA · eff. 2026-09-23 filed Medicare figure
- TRIJARDY XR 10-5-1,000 MG TAB $11.2774 per EA · eff. 2026-09-23 filed Medicare figure
- TRIJARDY XR 12.5-2.5-1,000 MG $5.62766 per EA · eff. 2026-09-23 filed Medicare figure
- TRIJARDY XR 25-5-1,000 MG TAB $11.23864 per EA · eff. 2026-09-23 filed Medicare figure
- TRIJARDY XR 5-2.5-1,000 MG TAB $5.66862 per EA · eff. 2026-09-23 filed Medicare figure
- XIGDUO XR 10 MG-1,000 MG TAB $19.20443 per EA · eff. 2026-09-23 filed Medicare figure
- XIGDUO XR 10 MG-500 MG TABLET $19.2391 per EA · eff. 2026-09-23 filed Medicare figure
- XIGDUO XR 2.5 MG-1,000 MG TAB $9.60825 per EA · eff. 2026-09-23 filed Medicare figure
- XIGDUO XR 5 MG-1,000 MG TABLET $9.59236 per EA · eff. 2026-09-23 filed Medicare figure
- XIGDUO XR 5 MG-500 MG TABLET $19.18159 per EA · eff. 2026-09-23 filed Medicare figure
- ZITUVIMET 50-1,000 MG TABLET $5.03055 per EA · eff. 2026-09-23 filed
- ZITUVIMET 50-500 MG TABLET $5.05824 per EA · eff. 2026-09-23 filed
- ZITUVIMET XR 100-1,000 MG TAB $10.07916 per EA · eff. 2026-09-23 filed
- ZITUVIMET XR 50-1,000 MG TABLET $5.01928 per EA · eff. 2026-09-23 filed
- ZITUVIMET XR 50-500 MG TABLET $5.00957 per EA · eff. 2026-05-20 filed
How to read these prices
OpenBill holds every page to these five rules, written by the project’s owner and quoted word for word:
- A price is a range to expect, never a quote.
- Medicare's price is not your price. Say so on every screen that shows it.
- State which dataset and which effective date produced every figure.
- If a source is stale or a file is empty, show that rather than a zero.
- Disclaimer footer: not medical advice, no warranty, other people's data can be wrong.