ADVAIR HFA 45-21 MCG INHALER

What it is

ADVAIR HFA 45-21 MCG INHALER is how the CMS NADAC file names this product. The FDA NDC Directory lists it as fluticasone propionate and salmeterol xinafoate, under the trade name “ADVAIR HFA”.

FDA gives its dosage form as aerosol, metered and its route as respiratory (inhalation).

The labeler, the company named on the label, is GlaxoSmithKline LLC.

FDA lists it under 2 Established Pharmacologic Classes: beta2-Adrenergic Agonist and Corticosteroid.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $19.98 – $20.02 for 1 g, depending on the NDC ($19.9752 to $20.01825 per GM), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

NADAC also lists, on the row of one brand NDC, what pharmacies pay for the generic equivalent, a different product: $16.6775 per GM filed.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

What NADAC measures · NADAC explanation codes

All 2 NDCs

• 00173-0715-20 · GlaxoSmithKline LLC · $19.9752 per GM · eff. 2026-09-23 filed
• 00173-0715-22 · GlaxoSmithKline LLC · $20.01825 per GM · eff. 2026-09-23 filed

Other strengths, forms and brands

5 other products in the NADAC file share the FDA nonproprietary name fluticasone propionate and salmeterol xinafoate with ADVAIR HFA 45-21 MCG INHALER.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 2 NDCs’ NADAC prices is $19.9752 per GM filed.

Of the 24 other products in FDA’s beta2-Adrenergic Agonist class priced per GM, 14 have a higher middle NADAC price and 10 a lower one. The one in the middle is BREYNA 160-4.5 MCG INHALER, at $21.61843 per GM filed (eff. 2026-09-23).

Of the 122 other products in FDA’s Corticosteroid class priced per GM, 22 have a higher middle NADAC price and 100 a lower one. The one in the middle is CALCIPOTRIENE-BETAMETHASONE DP 0.005%-0.064% OINTMENT, at $1.43306 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $28.71 for 1 g, at an average of $28.71328 per GM in 2024 (2024-01-01 to 2024-12-31) for “Advair HFA” and “Fluticasone Propion/Salmeterol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 715,505 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $19.9752 to $20.01825 per GM for this product, depending on the NDC.
• Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: FLUTICASONE-SALMETEROL 45-21. Ask your pharmacist or prescriber; do not switch on your own.
• How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.