FLUTICASONE-SALMETEROL 45-21

What it is

FLUTICASONE-SALMETEROL 45-21 is how the CMS NADAC file names this product. The FDA NDC Directory lists it as fluticasone propionate and salmeterol xinafoate, under the trade name “Fluticasone Propionate and Salmeterol HFA”.

FDA gives its dosage form as aerosol, metered and its route as respiratory (inhalation).

The labeler, the company named on the label, is Prasco Laboratories.

FDA lists it under 2 Established Pharmacologic Classes: beta2-Adrenergic Agonist and Corticosteroid.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 66993-0086-96.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $16.68 for 1 g (1 × $16.6775 per GM, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

The NDC

• 66993-0086-96 · Prasco Laboratories · $16.6775 per GM · eff. 2026-09-23 filed

Other strengths, forms and brands

5 other products in the NADAC file share the FDA nonproprietary name fluticasone propionate and salmeterol xinafoate with FLUTICASONE-SALMETEROL 45-21.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

Its NADAC price is $16.6775 per GM filed.

Of the 24 other products in FDA’s beta2-Adrenergic Agonist class priced per GM, 19 have a higher middle NADAC price and 5 a lower one. The one in the middle is BREYNA 160-4.5 MCG INHALER, at $21.61843 per GM filed (eff. 2026-09-23).

Of the 122 other products in FDA’s Corticosteroid class priced per GM, 29 have a higher middle NADAC price and 93 a lower one. The one in the middle is CALCIPOTRIENE-BETAMETHASONE DP 0.005%-0.064% OINTMENT, at $1.43306 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

We don’t know yet; the card above says why.

Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.