DESOXIMETASONE 0.25% CREAM

What it is

DESOXIMETASONE 0.25% CREAM is how the CMS NADAC file names this product. The FDA NDC Directory lists it as desoximetasone.

FDA gives its dosage form as cream and its route as topical.

FDA lists 4 labelers (the companies named on the label) for its NDCs, among them Padagis Israel Pharmaceuticals Ltd, Lupin Pharmaceuticals, Inc. and Saptalis Pharmaceuticals, LLC.

FDA’s Established Pharmacologic Class for it is Corticosteroid.

The NADAC file of 2026-10-14 prices it under 10 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.32 – $0.45 for 1 g, depending on the NDC ($0.32267 to $0.44737 per GM), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

The 4 labelers

Other strengths, forms and brands

5 other products in the NADAC file share the FDA nonproprietary name desoximetasone with DESOXIMETASONE 0.25% CREAM.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-03-18, 2026-08-19, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 10 NDCs’ NADAC prices is $0.39788 per GM filed.

Of the 122 other products in FDA’s Corticosteroid class priced per GM, 81 have a higher middle NADAC price and 41 a lower one. The one in the middle is DESOXIMETASONE 0.05% CREAM, at $1.50996 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $1.11 for 1 g, at an average of $1.11095 per GM in 2024 (2024-01-01 to 2024-12-31) for “Desoximetasone”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 46,030 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.32267 to $0.44737 per GM for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.