ESTRACE 0.01% CREAM

What it is

ESTRACE 0.01% CREAM is how the CMS NADAC file names this product. The FDA NDC Directory lists it as estradiol, under the trade name “ESTRACE”.

FDA gives its dosage form as cream and its route as vaginal.

The labeler, the company named on the label, is Allergan, Inc.

FDA’s Established Pharmacologic Class for it is Estrogen.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00430-3754-14.

NADAC classes it in its brand rate-setting class B-ANDA, and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $329.86 for 42.5 g (42.5 × $7.76131 per GM, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

NADAC also lists, on the row of one brand NDC, what pharmacies pay for the generic equivalent, a different product: $0.46452 per GM filed.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

What NADAC measures · NADAC explanation codes

The NDC

• 00430-3754-14 · Allergan, Inc. · $7.76131 per GM · eff. 2026-09-23 filed

Other strengths, forms and brands

59 other products in the NADAC file share the FDA nonproprietary name estradiol with ESTRACE 0.01% CREAM. The 23 below share a strength or dosage form with it first; search OpenBill for the rest.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

Its NADAC price is $7.76131 per GM filed.

Of the 8 other products in FDA’s Estrogen class priced per GM, 1 has a higher middle NADAC price and 7 a lower one. The one in the middle is ESTRADIOL 0.06% 1.25G GEL PUMP, at $3.38721 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $255.35 for 42.5 g, at an average of $6.00834 per GM in 2024 (2024-01-01 to 2024-12-31) for “Estrace*” and “Estradiol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 6,218 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 42.5 g? Is it lower than what I would pay through my insurance?
• Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: ESTRADIOL 0.01% CREAM. Ask your pharmacist or prescriber; do not switch on your own.
• How much is in the package I am getting? This page uses 42.5 g; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.