ESTRADIOL 0.1% (0.5 MG) GEL PKT

What it is

ESTRADIOL 0.1% (0.5 MG) GEL PKT is how the CMS NADAC file names this product. The FDA NDC Directory lists it as “estradiol”, “estradiol gel 0.1%” and “estradiol transdermal”, as its NDCs’ listings variously write the nonproprietary name, under the trade name “Estradiol Gel”.

FDA gives its dosage form as gel and its route as topical.

FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Trigen Laboratories, LLC, Encube Ethicals, Inc. and Padagis Israel Pharmaceuticals Ltd.

FDA’s Established Pharmacologic Class for it is Estrogen.

The NADAC file of 2026-10-14 prices it under 7 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.95 for 1 unit (EA) (1 × $0.95477 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

The 7 labelers

Other strengths, forms and brands

59 other products in the NADAC file share an FDA nonproprietary name with ESTRADIOL 0.1% (0.5 MG) GEL PKT. The 23 below share a strength or dosage form with it first; search OpenBill for the rest.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 7 NDCs’ NADAC prices is $0.95477 per EA filed.

Of the 104 other products in FDA’s Estrogen class priced per EA, 80 have a higher middle NADAC price and 24 a lower one. The one in the middle is DOTTI 0.0375 MG PATCH, at $8.26227 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

We don’t know yet; the card above says why.

Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 unit (EA)? Is it lower than what I would pay through my insurance?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.