EYSUVIS 0.25% EYE DROPS
FDA nonproprietary name: loteprednol etabonate
For 8.3 mL
Pharmacies pay
$510.55 filed
8.3 × $61.51166 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$487.85 filed
8.3 × $58.7776 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
0.96× estimated
Medicare paid about what pharmacies pay.
Part D averages every strength and form sold under “Eysuvis” / “Loteprednol Etabonate” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$592.13 estimated
$510.55 + $76.58 (15%) + $5.00 fee per fill = $592.13
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
EYSUVIS 0.25% EYE DROPS is how the CMS NADAC file names this product. The FDA NDC Directory lists it as loteprednol etabonate, under the trade name “Eysuvis”.
FDA gives its dosage form as suspension/ drops and its route as ophthalmic.
The labeler, the company named on the label, is ALCON LABORATORIES, INC.
FDA’s Established Pharmacologic Class for it is Corticosteroid.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 71571-0333-83.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $510.55 for 8.3 mL (8.3 × $61.51166 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
The NDC
- 71571-0333-83 · ALCON LABORATORIES, INC. · $61.51166 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
7 other products in the NADAC file share the FDA nonproprietary name loteprednol etabonate with EYSUVIS 0.25% EYE DROPS.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| ALREX 0.2% EYE DROPS | $58.01 to $58.04442 per ML filed | $55.82528 per ML filed |
| EYSUVIS 0.25% EYE DROPS this page | $61.51166 per ML filed | $58.7776 per ML filed |
| LOTEMAX 0.5% EYE OINTMENT | $99.7438 per GM filed | $88.6467 per GM filed |
| LOTEMAX 0.5% OPHTHALMIC GEL | $49.66158 per GM filed | $88.6467 per GM filed |
| LOTEMAX SM 0.38% OPHTH GEL | $49.48461 per GM filed | $49.86513 per GM filed |
| LOTEPREDNOL 0.5% OPHTHALMC GEL | $18.18798 per GM filed | We don’t know yet |
| LOTEPREDNOL ETABONATE 0.2% DRP | $30.71714 per ML filed | We don’t know yet |
| LOTEPREDNOL ETABONATE 0.5% DRP | $10.47371 to $21.199 per ML filed | We don’t know yet |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-07-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
Its NADAC price is $61.51166 per ML filed.
Of the 106 other products in FDA’s Corticosteroid class priced per ML, 1 has a higher middle NADAC price and 105 a lower one. The one in the middle is FLUNISOLIDE 0.025% SPRAY, at $1.98777 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $487.85 for 8.3 mL, at an average of $58.7776 per ML in 2024 (2024-01-01 to 2024-12-31) for “Eysuvis” and “Loteprednol Etabonate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 25,219 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 8.3 mL? Is it lower than what I would pay through my insurance?
- How much is in the package I am getting? This page uses 8.3 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for EYSUVIS 0.25% EYE DROPS labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Eysuvis / Loteprednol Etabonate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 8.3 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 8.3 mL in one package for this product’s NDC (“1 BOTTLE, DROPPER in 1 CARTON (71571-333-83) / 8.3 mL in 1 BOTTLE, DROPPER”), so the card starts at one package: 8.3 ML. Change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- PREDNISONE 1 MG TABLET
- TRELEGY ELLIPTA 100-62.5-25
- METHYLPREDNISOLONE 16 MG TAB
- PREDNISOLONE AC 1% EYE DROP
- BREO ELLIPTA 100-25 MCG INHALR