FLUTICASONE-SALMETEROL 500-50

What it is

FLUTICASONE-SALMETEROL 500-50 is how the CMS NADAC file names this product. The FDA NDC Directory lists it as fluticasone propionate and salmeterol, under the trade name “Fluticasone Propionate and Salmeterol DISKUS”.

FDA gives its dosage form as powder and its route as respiratory (inhalation).

Its labelers, the companies named on the label, are Hikma Pharmaceuticals USA Inc., Teva Pharmaceuticals USA, Inc. and Prasco Laboratories.

FDA lists it under 2 Established Pharmacologic Classes: beta2-Adrenergic Agonist and Corticosteroid.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $1.64 for 1 unit (EA) (1 × $1.63625 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

All 3 NDCs

• 00054-0328-56 · Hikma Pharmaceuticals USA Inc. · $1.63625 per EA · eff. 2026-09-23 filed
• 00093-7516-31 · Teva Pharmaceuticals USA, Inc. · $1.63625 per EA · eff. 2026-09-23 filed
• 66993-0586-97 · Prasco Laboratories · $1.63625 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

11 other products in the NADAC file share the FDA nonproprietary name fluticasone propionate and salmeterol with FLUTICASONE-SALMETEROL 500-50.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23, 2026-10-07 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $1.63625 per EA filed.

Of the 26 other products in FDA’s beta2-Adrenergic Agonist class priced per EA, 18 have a higher middle NADAC price and 7 a lower one; 1 has the same. The one in the middle is ADVAIR 500-50 DISKUS, at $4.2281 per EA filed (eff. 2026-09-23).

Of the 73 other products in FDA’s Corticosteroid class priced per EA, 39 have a higher middle NADAC price and 33 a lower one; 1 has the same. The one in the middle is ADVAIR 100-50 DISKUS, at $2.48669 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $8.70 for 1 unit (EA), at an average of $8.70295 per EA in 2024 (2024-01-01 to 2024-12-31) for “Fluticasone-Salmeterol” and “Fluticasone Propion/Salmeterol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 2,594,479 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 unit (EA)? Is it lower than what I would pay through my insurance?
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.