SIMBRINZA 1%-0.2% EYE DROP

What it is

SIMBRINZA 1%-0.2% EYE DROP is how the CMS NADAC file names this product. The FDA NDC Directory lists it as brinzolamide/brimonidine tartrate, under the trade name “SIMBRINZA”.

FDA gives its dosage form as suspension/ drops and its route as ophthalmic.

The labeler, the company named on the label, is Alcon Laboratories, Inc.

FDA lists it under 2 Established Pharmacologic Classes: alpha-Adrenergic Agonist and Carbonic Anhydrase Inhibitor.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00065-4147-27.

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $208.31 for 8 mL (8 × $26.03918 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

The NDC

• 00065-4147-27 · Alcon Laboratories, Inc. · $26.03918 per ML · eff. 2026-09-23 filed

Compared with its class

Its NADAC price is $26.03918 per ML filed.

Of the 14 other products in FDA’s alpha-Adrenergic Agonist class priced per ML, 3 have a higher middle NADAC price and 11 a lower one. The one in the middle is BRIMONIDINE-TIMOLOL 0.2%-0.5%, at $2.15126 per ML filed (eff. 2026-09-23).

Of the 5 other products in FDA’s Carbonic Anhydrase Inhibitor class priced per ML, 1 has a higher middle NADAC price and 4 a lower one. The one in the middle is BRINZOLAMIDE 1% EYE DROPS, at $8.52641 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $200.44 for 8 mL, at an average of $25.05442 per ML in 2024 (2024-01-01 to 2024-12-31) for “Simbrinza” and “Brinzolamide/Brimonidine Tart”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 301,984 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 8 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 8 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.