HYDROMORPHONE 5 MG/5 ML SOLN
For 473 mL
Pharmacies pay
$111.57 filed
473 × $0.23587 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare
We don’t know yet
No Medicare reference price. Part D: OpenBill did not match this NDC to a usable Medicare Part D spending row. Either Part D has none for it, or the rows that share its name could not safely be tied to it (for example, they mix units, routes or release forms, or the drug is sold over the counter, which Part D does not cover). Part B: This NDC is not in the current quarter’s Medicare Part B NDC-HCPCS crosswalk, so it has no Part B payment limit.
The spread
We don’t know yet
There is no Medicare figure to compare with, so there is no spread.
Cost-plus estimate
$133.31 estimated
$111.57 + $16.74 (15%) + $5.00 fee per fill = $133.31
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
HYDROMORPHONE 5 MG/5 ML SOLN is how the CMS NADAC file names this product. The FDA NDC Directory lists it as hydromorphone hydrochloride.
FDA gives its dosage form as solution and its route as oral.
The labeler, the company named on the label, is Rhodes Pharmaceuticals LLC.
FDA’s Established Pharmacologic Class for it is Opioid Agonist.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 42858-0304-16.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $111.57 for 473 mL (473 × $0.23587 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.
What NADAC measures · NADAC explanation codes
The NDC
- 42858-0304-16 · Rhodes Pharmaceuticals LLC · $0.23587 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
12 other products in the NADAC file share the FDA nonproprietary name hydromorphone hydrochloride with HYDROMORPHONE 5 MG/5 ML SOLN.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| HYDROMORPHONE 1 MG/ML SOLUTION | $0.23587 per ML filed | We don’t know yet |
| HYDROMORPHONE 2 MG TABLET | $0.16941 per EA filed | We don’t know yet |
| HYDROMORPHONE 2 MG/ML VIAL | $2.74032 per ML filed | $4.48 per ML derived |
| HYDROMORPHONE 4 MG TABLET | $0.21916 per EA filed | We don’t know yet |
| HYDROMORPHONE 5 MG/5 ML SOLN this page | $0.23587 per ML filed | We don’t know yet |
| HYDROMORPHONE 8 MG TABLET | $0.56093 per EA filed | We don’t know yet |
| HYDROMORPHONE 10 MG/ML VIAL | $2.56628 per ML filed | $22.40 per ML derived |
| HYDROMORPHONE 50 MG/5 ML VIAL | $2.56628 per ML filed | $22.40 per ML derived |
| HYDROMORPHONE 500 MG/50 ML VIAL | $2.56628 per ML filed | $22.40 per ML derived |
| HYDROMORPHONE 500 MG/50 ML VL | $2.56628 per ML filed | $22.40 per ML derived |
| HYDROMORPHONE HCL ER 8 MG TAB | $5.7288 per EA filed | $8.02501 per EA filed |
| HYDROMORPHONE HCL ER 12 MG TAB | $10.42125 per EA filed | $8.02501 per EA filed |
| HYDROMORPHONE HCL ER 16 MG TAB | $12.38018 per EA filed | $8.02501 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-05-20, 2026-07-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
Its NADAC price is $0.23587 per ML filed.
Of the 31 other products in FDA’s Opioid Agonist class priced per ML, 18 have a higher middle NADAC price and 12 a lower one; 1 has the same. The one in the middle is ACETAMINOPHEN-CODEINE 120 MG-12 MG/5 ML SOLUTION, at $0.46877 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
We don’t know yet; the card above says why.
Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 473 mL? Is it lower than what I would pay through my insurance?
- How much is in the package I am getting? This page uses 473 mL; your package may hold a different amount.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why does this page start at 473 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 473 mL in one package for this product’s NDC (“473 mL in 1 BOTTLE, PLASTIC (42858-304-16)”), so the card starts at one package: 473 ML. Change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- TRAMADOL HCL 100 MG TABLET
- OXYCODONE-ACETAMINOPHEN 10-325 MG TAB
- FENTANYL 100 MCG/HR PATCH
- METHADONE HCL 10 MG TABLET
- TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB