HYDROMORPHONE 500 MG/50 ML VL

What it is

HYDROMORPHONE 500 MG/50 ML VL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as hydromorphone hydrochloride.

FDA gives its dosage form as injection, solution and its route as intramuscular; intravenous; subcutaneous.

The labeler, the company named on the label, is Fresenius Kabi USA, LLC.

FDA’s Established Pharmacologic Class for it is Opioid Agonist.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 63323-0851-50.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $128.31 for 50 mL (50 × $2.56628 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-05-20. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 4, carried forward from the previous file; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

This NDC’s NADAC was carried forward from an earlier file (NADAC explanation code 2 or 4), not newly surveyed: it took effect on 2026-05-20. The file is new; the price is not.

What NADAC measures · NADAC explanation codes · Carried-forward prices

The NDC

• 63323-0851-50 · Fresenius Kabi USA, LLC · $2.56628 per ML · eff. 2026-05-20 filed carried forward

Other strengths, forms and brands

12 other products in the NADAC file share the FDA nonproprietary name hydromorphone hydrochloride with HYDROMORPHONE 500 MG/50 ML VL.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-05-20, 2026-07-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)

Compared with its class

Its NADAC price is $2.56628 per ML filed.

Of the 31 other products in FDA’s Opioid Agonist class priced per ML, 2 have a higher middle NADAC price and 26 a lower one; 3 have the same. The one in the middle is MORPHINE SULF 100 MG/5 ML CONC, at $0.39203 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-05-20, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part B’s payment limit for HCPCS J1171, for 2026-10-01 to 2026-12-31, comes to $1,120.00 for 50 mL, or $22.40 per ML once converted to NADAC’s unit for this product.

Medicare Part B pays for a drug like this only in specific settings, such as a drug given in a clinic or doctor’s office or used with certain medical equipment; most prescriptions filled at a pharmacy are paid by Part D.

The patient’s share under Part B (coinsurance, 20% of the limit, before deductibles and other coverage) is $0.0448 per 0.1 MG.

Medicare's price is not your price.

What the Part B payment limit is · Converting it to the NADAC unit · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 50 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 50 mL; your package may hold a different amount.
• If you have Medicare Part B: is this drug covered for me in this setting, and what is my share?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.