M-DRYL 12.5 MG/5 ML SOLUTION

What it is

M-DRYL 12.5 MG/5 ML SOLUTION is how the CMS NADAC file names this product. The FDA NDC Directory lists it as diphenhydramine hydrochloride, under the trade name “M-Dryl”.

FDA gives its dosage form as liquid and its route as oral.

The labeler, the company named on the label, is Method Pharmaceuticals, LLC.

FDA’s Established Pharmacologic Class for it is Histamine-1 Receptor Antagonist.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and marks it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.02 for 1 mL, depending on the NDC ($0.01744 to $0.01921 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 2 NDCs

• 58657-0528-04 · Method Pharmaceuticals, LLC · $0.01921 per ML · eff. 2026-09-23 filed
• 58657-0528-16 · Method Pharmaceuticals, LLC · $0.01744 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

24 other products in the NADAC file share the FDA nonproprietary name diphenhydramine hydrochloride with M-DRYL 12.5 MG/5 ML SOLUTION. The 23 below share a strength or dosage form with it first; search OpenBill for the rest.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 2 NDCs’ NADAC prices is $0.01744 per ML filed.

Of the 46 other products in FDA’s Histamine-1 Receptor Antagonist class priced per ML, 40 have a higher middle NADAC price and 4 a lower one; 2 have the same. The one in the middle is ED-A-HIST DM LIQUID, at $0.06691 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

We don’t know yet; the card above says why.

Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.01744 to $0.01921 per ML for this product, depending on the NDC.
• It is sold over the counter, so shelf prices vary from store to store: what does it cost per unit here?
• How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.